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Footnotes Funding This work has been supported by the Science and Engineering Research Board, Government of India [ECR/2017/000231], Start up Grant, University Grant Commission, Government of India, India [F30-363/2017(BSR)] and University Grant Commission, Government of India, India [UGC-UPE, Phase II].

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doi: 10.1074/jbc.M808691200

Another mechanism of betaine protection is by influencing gut osmolality and potentially altering intestinal pH, which enhancing digestive enzyme activity, restoring intestinal morphology, and increasing microbiota diversity (35)