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New Chin Med Clin Pharmacol

Storage Lyophilizate (dry powder before reconstitution) 2 years at 20 C (freezer) 12 months at 28 C (refrigerator) Only short-term (up to 14 days) at room temperature, Cagrilintide is more sensitive to aggregation at higher temperatures Protect from light and moisture After reconstitution (peptide in solution with bacteriostatic water) Up to 21 days at 28 C , protected from light Cagrilintide has slightly shorter shelf life than Semaglutide because of its amyloid tendency Practical storage rules Allow the vial to warm to room temperature (1520 min) before opening

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In addition, continuous use for more than one year increases the half-life of the drug to 1.3 days, and on the other hand, obesity can decrease the half-life, increasing clearance by up to 50% [47]

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