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In the next, extremely unfavorable elimination step (step 2), the conjugate base of the amine is kicked out from the tetrahedral intermediate: The reaction is driven to completion in a quick, irreversible deprotonation of the carboxylic acid by the newly formed RNH

Figure 3 4 Discussion This study highlighted the multi-faceted impact of GABA supplementation, and combination therapy (GABA, probiotics, VD3, and EAAT2 activator, -lactam) on neurotransmitter balance, oxidative stress and social behavior in PPA-induced rodent model of autism

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doi: 10.1002/eji.1830240928 67 DamJGuanRNatarajanKDimasiNChlewickiLKKranzDMet al

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