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In studies of human glioblastoma, the absence of exogenous Gln significantly reduces glutamate levels, resulting in the conversion of the dimer GLS1 into a self-assembled, extremely low Km filamentous polymer that further depletes intracellular Gln

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Here we seek to examine the theoretical dependence of GSH on vitamin B 12 with a mathematical model of 1-carbon metabolism due to Reed and co-workers

The reversibility of DNA methylation marks provides a therapeutic opportunity to dynamically regulate gene expression, which is especially appealing in chronic autoimmune disorders where immune cell plasticity is essential ( The emergence of methylation biomarkers enhances the application of personalized medicine strategies in AS

[DOI] [PubMed] [Google Scholar] Bolaos, J

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