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Upon stimulation, we observed a significant increase in the accumulation of peroxidized lipids in T cell membranes (Fig

FIGURE 4 5.5 Challenges and prospects of antioxidant therapy Antioxidant therapy in the context of CNS diseases is confronted with numerous challenges, such as the high incidence of failed clinical trials, the intricate role of oxidative stress in disease pathology, the impediment posed by the blood-brain barrier to drug permeation, and the specific needs for activators of antioxidant enzymes

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The antioxidative and anti-inflammatory benefits observed in preclinical work also support its role in mitigating secondary injury cascades

[DOI] [PubMed] [Google Scholar] [91].Hamanishi T, Furuta H, Kato H, Doi A, Tamai M, Shimomura H, Sakagashira S, Nishi M, Sasaki H, Sanke T, Nanjo K, Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in japanese type 2 diabetic patients

Vet Immunol Immunopathol 74(3-4):315-327