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Glutathione and the Immune System

In patients with CP/CPPS (particularly NIH types III and IV), clinical studies based on 16S rRNA and metagenomic sequencing have confirmed that the homeostasis of the genitourinary microecosystem is disrupted, presenting a characteristic pattern of depletion of protective flora and enrichment of pathogenic flora. Specifically, in patient semen or prostatic fluid samples, the abundance of Lactobacillus species, which possess probiotic and anti-inflammatory properties, is significantly decreased, while the abundance of opportunistic pathogens represented by the phylum Proteobacteria (e.g., Pseudomonas, Escherichia) and Streptococcus is significantly increased (176, 177)

LC could increase the expression of superoxide dismutase-2 (SOD-2), reduce inflammation, and alleviate oxidative stress in animal models [13]

Inflammatory bowel disease: mechanisms, redox considerations, and therapeutic targets

Aquaculture 587, 740874

These can be age, family history, malnutrition, smoking, stress, or heavy UV radiation exposure [5] [6] [7] [8]