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Using sterile water can lead to reduced efficacy and altered pharmacokinetics, which may increase safety concerns

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Low folate and B 12 concentrations have been correlated with depressive disorders (Reference Wesson, Levitt and Joffe10Reference Bell, Edman and Morrow15) , while evidence has suggested that both of these vitamins may enhance the effectiveness of antidepressants (Reference Almeida, Ford and Hirani16)

OHCbl was changed from IV to IM administration at day 8 of life

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