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Since D1-3 are selenoproteins, selenium deficiency would be expected to result in their reduced activities in different tissues, although this effect is observed only for D1 in the liver and kidney and not for D2 and D3 in other tissues (48)

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First, a toxic loop involving ferroptosis, -synuclein, and neuromelanin exists in the PD microenvironment, yet this study has not clarified the bidirectional regulation between ferroptosis and -synuclein oligomersspecifically, whether oligomers disrupt LIP homeostasis to trigger ferroptosis, or how lipid peroxidation products from ferroptosis accelerate protein aggregation