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Glutathione levels also increased significantly in IF

Abstract Glutathione-mediated biotransformation in the liver is a well-known detoxification process to eliminate small xenobiotics, but its impacts on nanoparticle retention, targeting and clearance are much less understood than liver macrophage uptake, even though both processes are involved in liver detoxification

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Physiol Rev 94:329354 Bianchi G, Caporali R, Todoerti M, Mattana P (2016) Methotrexate and rheumatoid arthritis: current evidence regarding subcutaneous versus oral routes of administration