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Among the multiple signaling pathways associated with glioblastoma, the HGF/c-MET and TGF- pathways have gained particular attention because of their putative roles in glioblastoma SC function 9,10,11 , in the development of invasiveness 12,13 and resistance to radiotherapy and chemotherapy 14,15,16,17 as well as targeted therapies 18

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To validate the functional role of the RAPTORmembrane interaction, we tested the RAPTOR F1296E and RAPTOR F1296E/M1297E constructs in inducible RAPTOR knockout mouse embryonic fibroblasts (MEFs) (Fig

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Upon binding CXCR2, CINC3 triggers downstream cascades that finely regulate neutrophil recruitment 37,38,39