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Plant-derived extracellular vesicles: recent advancements and current challenges on their use for biomedical applications

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[6] Neuroprotective and Neurorestorative Effects of Thymosin Beta 4 Treatment Following Experimental Traumatic Brain Injury NIH

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For instance, although temozolomide can cross the BBB and is therefore commonly employed in clinics to treat gliomas, the response rate of this treatment is only approximately 40% of patients owing to the expression of O6-methylguanine DNA methyltransferase 18 and even goes down to 20% for those suffering from higher-grade gliomas 19

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