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Homocysteine is a potentially toxic byproduct of protein metabolism that the body clears with the help of B12

Some compounds frequently compared to NAD+ (MOTS-c, 5-amino-1MQ) actually depend on NAD+ to do their job, making them complementary rather than competing options

Annals of the New York Academy of Sciences, 387-406, 1986

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Apparently by the ALT method (shorts can template off longs), plus their cells have massive contact inhibition controls to stop cancerous growth (that one would imagine could hijack enhanced ALT)