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At least three structures are known for a coordination number of seven, which is generally found for only large metal ions

Studies suggest that the copper(II) ion is essential for biological activity, as the apo-peptide (GHK without copper) shows reduced activity

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Mechanism and gene expression Pickart and colleagues used Broad Institute Connectivity Map data to show GHK-Cu modulates expression of more than 4,000 human genes, with shifts toward patterns associated with younger tissue

Contrast sensitivity: Simple tests available online or printable