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Ageing is often accompanied by a demyelination process, which is associated with increased levels of DNA oxidative damage in aged oligodendrocytes

J Nanobiotechnol 1(10):18 Friedman JK, Nitta CH, Henderson KM, Codianni SJ, Sanchez L, Ramiro-Diaz JM, Howard TA, Giermakowska W, Kanagy NL, Gonzalez Bosc LV (2014) Intermittent hypoxia-induced increases in reactive oxygen species activate NFATc3 increasing endothelin-1 vasoconstrictor reactivity

Cancer Nanobombs Delivering Artoxplatin with a Polyigniter Bearing Hydrophobic Ferrocene Units Upregulate PD-L1 Expression and Stimulate Stronger Anticancer Immunity

All these results suggest that the mitochondrial networks morphology and integrity are compromised in all fibroblasts from AD patients and that these changes are much more evident in APOE 3/4 + PSEN1 fibroblasts and in APOE 4/4

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