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Supplementing with peptides, comes with risks

Effect of food consumption on the pharmacokinetics, safety, and tolerability of once-daily orally administered orforglipron (LY3502970), a non-peptide GLP-1 receptor agonist

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Since B12 is primarily found in animal products, those on plant-based diets, as well as individuals with certain health conditions, may be at risk of deficiency and could benefit from supplementation

Regular or heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut, making the supplement less effective

limited evidence