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Hormones, inflammation, poor circulation, nutrient deficiencies, oxidative stress, and structural weakness all contribute

Bell CJM, Mehta M, Mirza L, Young AH, Beck K

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10.1016/j.ejphar.2019.01.006 267 ZhaoJ

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This can be accomplished by administering to an animal a population of recombinant genetic vaccine vectors by the chosen route of administration and, at various times thereafter excise the target tissue and recover vector from the tissue by standard molecular biology procedures