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Molecules , 2020 Improved Gut Microcirculation The peptide enhances angiogenesis the formation of new capillarieswhich is essential for delivering oxygen and nutrients to damaged gut tissue, especially in the presence of ulcers or IBD-related lesions

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Recurrent episodes in a separate pre-clinical OM model also demonstrated continuous microevolution of a haemoglobin-binding gene that resulted in a highly invasive NTHi phenotype that persisted for at least one month following clinical resolution of the infection (Harrison et al., 2020)

(Although multiple sclerosis (MS) is classically an autoimmune inflammatory demyelinating disease rather than a primary proteinopathy, we include it here due to overlapping chronic CNS injury and immune dysregulation influenced by the microbiome.) For each disease, specific microbial taxa, metabolites, and pathways implicated in pathogenesis are discussed

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doi: 10.1371/journal.pone.0017599