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Location Is the Key to Function: HMGB1 in Sepsis and Trauma-Induced Inflammation

Biochem J 450:6372 Navrot N, Collin V, Gualberto J, Gelhaye E, Hirasawa M, Rey P, Knaff DB, Issakidis E, Jacquot JP, Rouhier N (2006) Plant glutathione peroxidases are functional peroxiredoxins distributed in several subcellular compartments and regulated during biotic and abiotic stresses

For analyzing the spontaneous activity, spontaneous events were identified as peaks in fluorescence above an empirically determined threshold

Liposomal delivery encapsulates the glutathione in phospholipid spheres, which protects it through the digestive system and allows it to be absorbed more effectively than standard glutathione capsules or tablets, which are largely degraded before reaching the bloodstream

doi: 10.1182/blood.2018886317 185 TavaresLPNegreiros-LimaGLLimaKME SilvaPMRPinhoVTeixeiraMMet al

Moreover, lipid metabolic disorder is essential for ferroptosis, because the executor of this cell death is lipid peroxidation, which triggers ion flux disturbances and ultimately plasma membrane permeabilization and fragmentation (127129)