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It should be noted that these fluorescence-based biodistribution studies provide qualitative and semi-quantitative information on local retention and tissue distribution rather than quantitative pharmacokinetic data, and no conclusions regarding systemic absorption or clearance kinetics were drawn from these experiments [34]

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Les premires expriences animales menes par Whipple dans les annes 1920, sur les enzymes hpatiques, les maladies du foie et lhmoglobine, dmontrrent que la consommation de foie et de ses extraits amliorait les cas danmie classique, ce qui ouvrit une voie de recherche pour lanmie pernicieuse, encore un grand mystre

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