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Fibroblasts secrete inflammatory cytokines and chemokines, such as tumor necrosis factor-alpha (TNF-), IL-1, and chemokine (C-X-C Motif) ligand 8 (CXCL8), contributing to the inflammatory environment

Epidemiological studies consistently demonstrate that elevated circulating BCAA levels are closely associated with increased risk of insulin resistance (IR) and type 2 diabetes mellitus (T2DM) (132, 133)

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PROTACs frequently fail to accumulate effectively in target tissues or subcellular compartments, while off-target deposition in organs such as the liver or adipose tissue may potentiate toxicity [10]

Start with tirzepatide monotherapy, titrate to therapeutic dose (12.515mg weekly), allow 1620 weeks to reach plateau, then reassess

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