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Disclosure of interest: nothing to discloser E-Posters - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.01 - ACUTE MANAGEMENT - Neither thrombolysis nor thrombectomy P2109 - ESOC25-1903 TRIIODOTHYRONINE TREATMENT REDUCES STROKE VOLUME AND IMPROVES NEUROLOGICAL FUNCTION IN A MOUSE MODEL OF ISCHEMIC STROKE Daniel Ullrich 1,2 , Heike Heuer 2,3 , Steffen Mayerl 2,3 , Dagmar Fhrer 2,3 , Christoph Kleinschnitz 1,2 , Friederike Langhauser 1,2 1 Department of Neurology, University Hospital Essen, Germany, Essen, Germany, 2 Center for Translational Neuro- and Behavioural Sciences (C-TNBS), University Hospital Essen, Germany, E, Germany, 3 Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University Duisburg-Essen, Germany, Essen, Germany Background and Aims: Thyroid hormones affect the central nervous system's response to various stimuli such as ischemic stroke

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f , i , Proposed fragmentation pathways of flavan-3,3,4-triol ( 4 ) for fragments observed in negative ( f ) and positive ( i ) ion ESI-MS

Abnormal TDP-43 phosphorylation and ubiquitination are pathognomonic of ALS and TDP-43 related FTD [42]