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IDO1 inhibitors have been tested in a variety of anti-cancer treatments, including epacadostat (Table 1), indoximod, and navoximod, but compared with the results of preclinical trials, the efficacy of IDO1 inhibitors alone have not been objectively reflected in the clinical trials (Soliman et al., 2016

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Furthermore, the interplay between GD and trace elements may exhibit a reciprocal causal relationship, as opposed to solely discussing a unidirectional causal relationship in this study