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Also, other characteristics of this medication make it potentially dangerous in certain susceptible individuals causing thyroid dysfunction and/or thyroiditis [20, 103]

In one study, some researchers used a CRISPR/Cas9 knockout screen to identify 10 drug-resistant genes, including C1orf115, a previously uncharacterized MDR gene that they named required for drug-induced death 1 (RDD1) (463)

Studies have shown that loading PTX, gemcitabine monophosphate (GEMP), and the intermediate products of gemcitabine metabolism onto EVs can overcome chemotherapy resistance [207]

2013 reported Phase 2 safety/tolerability of the AOD9604 modified form in obesity

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