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We also showed that while uninfected macrophages exclusively use glucose and fatty acids as major sources of energy, latently HIV infected macrophages use glutamine/glutamate as a significant source and gain the capability to shift from one metabolic source to another

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For most women, the clinical conversation ends at oral contraceptives for cycle regulation, metformin for insulin resistance, and the diffuse instruction to "lose weight." What it rarely includes is any serious engagement with the signaling dysfunctions that make PCOS resistant to those blunt interventions in the first place

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