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Various parameters such as volume distribution, median residence time, clearance rates, elimination half-life, and distribution/absorption phase were also affected differently by the two treatments for different vitamins and minerals

[DOI] [PubMed] [Google Scholar] 223

Hansen PJ

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In a study by Hou et al (97) on a combination of metformin and the glycolysis inhibitor 2-DG in NSCLC treatment, enhanced DNA damage, DNA adduct formation, intracellular reactive oxygen species levels and mitochondrial membrane potential alteration, as well as increased apoptosis, caspase-3 activity, p-p38 and p-AMPK levels, were observed, indicating that combined treatment was more effective against NSCLC than either drug alone