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Recently, systematic frameworks integrating data-driven approach of omics data with mechanistic metabolic models represent a state-of-the-art strategy for investigating complex cellular metabolism and developing upstream bioprocess 22 , such as media development 25,26,55 and metabolic reprogramming observed during CHO cell long-term culture 9

The first 30 principal components were used for unsupervised cell clustering with a resolution = 0.3, yielding a total of 22 cell clusters using the FindNeighbours and FindClusters functions

Chiens : 0,05 0,1 mg de cyanocobalamine par kg de poids corporel, soit 0,5 1 ml de solution pour 10 kg de poids corporel Chats, chiens nains : 0,1 mg de cyanocobalamine par kg de poids corporel, soit 0,5 ml de solution par animal

83, 61376141 10.1073/pnas.83.16.6137 [DOI] [PMC free article] [PubMed] [Google Scholar] Schweizer E., Angst W., Lutz H

Statements Author contributions GJ: Conceptualization, Data curation, Formal Analysis, Investigation, Methodology, Software, Visualization, Writing original draft, Writing review & editing

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