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Conclusion BDNF trafficking in the regulated secretory pathway is a tightly regulated process that involves the action of multiple proteins working in tandem to ensure the proper sorting of BDNF to the RSP, facilitate vesicle maturation, recruit motor proteins, and facilitate exocytosis

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Sphingosine 1-phosphate (S1P) carrier-dependent regulation of endothelial barrier: high density lipoprotein (HDL)-s1p prolongs endothelial barrier enhancement as compared with albumin-s1p via effects on levels, trafficking, and signaling of S1p1 *