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doi: 10.1016/j.biomaterials.2007.12.002

Existing evidence points toward melatonins role as an antioxidant showing systemic therapeutic benefits in PD-relevant clinical trials (dyskinesia, sleep disorder) 187 , which combined with amphiphilic nature allowing for BBB diffusion further encourages therapeutic focus revisiting melatonin as a mitophagy agonist with NF-B and Nrf2 activating effect mentioned prior 187

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Acs Chem

We find that the loss of GCLC across all tissues of adult animals results in rapid weight loss and death

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