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Introduction Brain Tumors and Metastases The term brain tumors refers to a mixed group of neoplasms growing inside the central nervous system (CNS) ( In adults, the global age-standardized rate of primary brain tumors is approximately 6.8 per 100,000, with the highest rates seen in Europe ( The only established treatment for high-grade astrocytomas consists of maximal surgical resection of the tumor, followed by concurrent radiation and chemotherapy with temozolomide (TMZ), prolonging the median survival by only four months (6)

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The model exhibited a highly significant fit, with an F -value of 452.49 and a P -value 0.05), indicating comparable protective effects

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Impaired melatonin level promotes breast, ovarian, prostate, hepatocellular, and other cancers