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3.1 In vivo and in vitro experiment Sun et al

At the higher recommended doses, there is a proportional increase in the concentrations of free and bound racemate

Excessive accumulation of glutamate in the extracellular space due to impaired uptake or excessive release can lead to excitotoxicity, a harmful process that triggers calcium overload, oxidative stress, and neuronal death

Pathologic, clinical, and physiologic correlations

377 Iron overload, following increased intake, which may in particular result from the use of iron-containing implants widely employed in orthopaedic surgery, 378 or can occur after haemorrhagic stroke, results in compensatory upregulation of glial iron transporters, and down-regulation of neuronal iron transporters, both aimed at neuroprotection