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Here we demonstrate that IGF1 directly stimulates Kitl/KITLG expression in gastrointestinal smooth muscles, the natural microenvironment for ICC and GIST [8,21,22], in GIST cells and in LX-2 cells derived from hepatic stellate cells [33], the presumed niche for KIT + hepatic progenitors [54], inflammatory cells [55] and hepatocellular carcinoma [25]

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15 Connection to Sleep : The gut-brain axis, a bidirectional communication system between the gastrointestinal system and the brain, plays a surprising role in sleep regulation

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American Journal of Physiology-Endocrinology and Metabolism, 2006