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Description

Cysteine metabolic circuitries: druggable targets in cancer

Excess iron ions disrupt the electron transport chain and reduce ATP synthesis in the mitochondria

& Sussman, N

Storage: Store at 20C to 25C (68F to 77F)

ROS accumulation occurs in GCLC-deficient T cells, where excessive ROS impairs mTOR activation, affecting the expression of c-MYC and nuclear factor of activated T cells (NFAT), and adversely impacts T cell metabolic reprogramming