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10.7860/JCDR/2015/11526.5599 J

doi:10.1016/j.freeradbiomed.2023.04.024 Alehagen U, Aaseth J, Lindahl TL, Larsson A, Alexander J

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Mitochondria as central hubs in synaptic modulation

In summary, by integrating high-content single-cell level imaging analyses with mechanistic studies, extensive preclinical therapeutic experiments and a Phase Ib clinical trial, our studies herein elucidate the AR +/- BCL-2 +/- PCa cell subpopulation dynamics and credentials BCL-2 as a vital therapeutic target in heterogeneous CRPC

By comparing an AGE-directed strategy with antioxidant repletion, this study aims to clarify whether targeting AGE-related molecular damage provides benefit beyond general redox support in the context of diet-associated reproductive dysfunction