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Chronic inflammation leads to cartilage destruction, bone erosion, and progressive joint deformity

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Itinerary DAY 01: TRANSFER TO THE LODGE Reception at the airport and transfer to the Lodge, where you will be welcomed with a delicious cocktail or tropical juice

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186,187,509,510 The accumulated DNA oxidative damage in AD hyper-activates the DNA damage sensor PARP-1, thereby reducing the concentration of cellular NAD + and suppressing the function of NAD + -SIRT1-PGC-1 axis, which in turn causes abnormal mitochondria