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Cmo acta el Epithalon

Verkman, A.S., Galietta, L.J.V

11,12 Beyond the GI tract, oxidative stress initiates pro-inflammatory responses and disrupts immune function, contributing to a range of systemic diseases

In lipopolysaccharide primed macrophages, capsaicin induced TRPV1 activation and Ca 2+ influx promote polarization toward an M2 macrophage phenotype characterized by anti-inflammatory properties, thereby improving the adipose tissue inflammatory microenvironment and attenuating insulin resistance (63)

The researchers concluded that GLP-1 therapy for obesity should include resistance training, optimal protein intake, and if needed, specific nutrients and pharmacological interventions to preserve muscle mass