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4.1 Complexity of GB biology Intra-tumoral heterogeneity, which has also been previously described in GB using single-cell RNA-seq profiling ( Redundant signaling pathways in gliomagenesis limit the effectiveness of targeted therapies that focus on a single gene or pathway, even when the tumors complete molecular profile is known

2B), indicative of an elevation of GSH export in response to cystine starvation

Studies performed in vitro or in vivo models have demonstrated that overexpression of PRDXs may either inhibit cancer development or promote cancer growth (48), depending on the specific PRDX family member and on the cancer context

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