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Iron overload and oxidative stress constitute the major triggers leading to liver injury and disease progression for most liver diseases

These reports have already caused a level of response from the regulatory bodies, for example, the European Medicine Agency (EMA) has revised its guideline in the September 25, 2018 excluding the use of Curcuma longa supplements in case of obstruction of the bile duct, cholangitis, liver disease, gallstones, and any other biliary diseases ( Conclusion The overall limited number of cases worldwide, and the few toxicity studies available together with the preliminary determinations of regulatory organs seems to exclude the possibility of an intrinsic toxicity of curcumin

Zhao L, Lu T, Gao L, Fu X, Zhu S, Hou Y

Toller-Kawahisa JE, Viacava PR, Palsson-McDermott EM, Nascimento DC, Cervantes-Silva MP, OCarroll SM, et al

In vitro (110 mM) protects hepatocytes and myocytes from lipid overload and oxidative stress by increasing -oxidation and reducing ROS

Obara Y, Imai T, Sato H, Takeda Y, Kato T, Ishii K