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doi: 10.1517/17425247.2016.1167035 100

Chronic administration of high doses of oral levocarnitine in patients with severely compromised renal function or in ESRD patients on dialysis may result in accumulation of the potentially toxic metabolites, trimethylamine and trimethylamine-N-oxide, since these metabolites are normally excreted in the urine

Academic Press, Cambridge Huang WJ, Zhang X, Chen WW (2016) Role of oxidative stress in Alzheimers disease

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In particular, the findings show that whole-body energy metabolism, which is known to be impaired in overt hypothyroidism, measured using indirect calorimetry, was not fully normalized in women with obesity and long-lasting hypothyroidism taking the right dose of levothyroxine in comparison with women who are obese without hypothyroidism. In an observational, retrospective study, Perseghin and colleagues analyzed data from a cohort of women with obesity but without diabetes and normal thyroid-stimulating hormone levels (range, 0.4-4 mUI/L) who attended a standard protocol for bariatric surgery between January 2013 and July 2019