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In another letter to the editor, Herbert et al

After adjustment in Model I, the coefficient was 0.006 (95% CI -0.027 to 0.016, p = 0.607)

52 Their similarity is rooted in the fact that both lactyl-CoA and acetyl-CoA are primarily generated from pyruvate, an intermediate product of glycolysis, and have similar molecular structures

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This is because women are usually smaller, have more body fat and have lower total body water content than men