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Furthermore, this review considers whether enhancing BCAA catabolism forms a potential future treatment strategy to promote metabolic health in insulin resistance and T2D

AMPK, in contrast to mTOR, functions as a detector of insufficient cellular energy (low ATP to 5adenosine monophosphate ratio)

Interventions that target oxidative stress may help treat ED resulting from endothelial dysfunction

Research has demonstrated that combining physical exercise with vitamin D supplements can greatly reduce the symptoms of sensory-motor neuropathy, such as tingling, pain, and numbness, while also improving tactile sensitivity and vibration perception in DPN patients (103)