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It is likely that the induction of tmTNF- mediated reverse signaling by itself does not explain all adverse events with anti-TNF- agents, but manipulation of this characteristic of anti-TNF therapies provides a route to rationally design safer and more broadly effective anti-TNF- agents with minimal or abrogated tmTNF- interaction

S-DCT and S-DDCT also have no or very low affinity for serotonergic (5-HT1-7) or other receptors including alpha- and beta-adrenergic, dopamine (D1-5), histamine (H1-3), muscarinic (M1-5), and benzodiazepine receptors

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Additional reporting by Julie Kendrick

Consequently, detectability in the context of standard testing is low

Rotating MOTS-c sites across abdomen, thigh, and flank is a common practice to reduce local irritation