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Type 2 diabetes is associated with islet amyloid formation followed by macrophage infiltration and activation in the pancreatic islets [13, 14]

Gomez and colleagues (2018) observed, in Trpml1 / mice, low extracellular Ca 2+ concentrations even with pharmacological stimulation and confirmed that ion efflux occurred through channel activity (Gmez et al., 2018)

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