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While we are not aware of any contra-indications for pregnant or nursing women, Radiance requires written consent from a primary care provider or OB/GYN for patients who are pregnant and/or nursing

Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management

Elevated NAD+ levels activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate numerous metabolic processes including fat oxidation, glucose metabolism, mitochondrial biogenesis, and cellular stress responses

Importantly, these effects occur without changes in food intake, indicating metabolic rather than anorectic mechanisms