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ERK and GSK3 activity are tightly regulated by neuronal activity making gephyrin phosphorylation a key mechanism for the coordination of structural remodeling of GABAergic synapses and network activity levels

This anti-inflammatory effect provides symptomatic relief while the deeper repair processes unfold over subsequent weeks

After centrifugation at 14,000 g at 4 C for 2 min, the supernatants were evaporated to dryness in a SpeedVac concentrator at 45 C for 90 min at 1.5 atm pressure