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Importantly, obesity can also worsen pre-existing T2 high asthma, highlighting that its impact is not limited to the obesity-driven asthma endotype but extends across asthma phenotypes [38]

MOTS-C has been shown to reverse these age-related metabolic changes by improving insulin sensitivity and promoting cellular energy production

Zhong H, Wang J, van Soest J, Geng H, Huang M, Cheng C, Rosenthal DI , Axelrod R, Galvin JM, Garden AS, Le QT, Eisenhauer E, Trotti A, Beitler JJ, Singh AK, Bonner JA, Jones CU, Dekker A, Zhang Z, Xiao Y