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As stated above, HepG2 cells differ from many hepatoma lines in their low CYP2E1 expression

Gralapp for graphical illustration

Lancet Microbe 6, 100949

Specifically, the plasma of gout patients exhibited enriched populations of classic monocytes, whereas intermediate monocytes were more prevalent in the plasma of healthy individuals ( In vitro assays delineated MSU crystals propensity to induce TH1 cells to overexpress miRNA-146a, implying that miRNA-146a acted as a transcriptional brake in monocytes, which was suppressed during acute inflammatory responses to MSU crystals

10.1016/j.kint.2021.10.028 83 McWilliamS