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doi: 10.1016/j.ccm.2010.07.004 11 AnheF

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Preclinical models indicate that co-administration of the Nrf2 inhibitor Brusatol with corticosteroids reduces iron overload and lipid peroxidation

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The takeaway: strong human data on the anchor, solid pharmacology on the amplifier, and a genuine gap where the blend itself would need its own trial

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Some protocols use a 5-days-on, 2-days-off schedule

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