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The analysis in this Appendix, in conjunction with the remainder of this document, demonstrates that this proposed rule is consistent with the regulatory philosophy and principles identified in Executive Orders 12866 and 13563, the RFA, and section 1102(b) of the Act

doi: 10.1016/j.mib.2017.07.003

Mittal et al., 2014)

Another challenge to overcome for the next-generation nanomedicines resides in the regulatory classification, because the lack of knowledge regarding biosafety and long-term effects of nanomaterials leads to a regulatory uncertainty and deficient standards and protocols for scale-up manufacturing and safe clinical uses [678,679]

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By recognizing these factors, we can take proactive steps to support gut health and prevent related issues