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A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

These data confirm a pioneering smaller study conducted in Wuhan, China [88] , which reported that elevated GGT levels were common among patients with severe COVID-19 and positively associated with a prolonged hospital stay and severity of disease

17 Briefly, hepatocytes were isolated by digestion with type II collagenase (17101015, Gibco, Grand Island, USA) and then separated by Percoll (P1644, Sigma-Aldrich, USA) for centrifugation

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Additionally, it inhibits the generation of inflammatory cytokines and T-cell activity