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Yet, under regulation of the ISR pathway an ATF4-mediated upregulation of NRF2 via CHAC1 activity was shown as well ( 2.3.1 The dual role of CHAC1 in cancer CHAC1s function in cancer is complex and highly context-dependent

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Similarly, these inhibitors dimerically bind to the allosteric site of Rv1098c, and lock the nearest active site in an open conformation